This is a list of events that occurred in the 2280s:
- The Chronicles Of Londo Mollari -Diplomat, Emperor, Martyr, and Self-described Fool (Earth edition) is published.
- Friday, January 14th, 2281
- John Sheridan's life force from Lorien finally ceases. He takes a Snub-nose Whitestar to Coriana VI, in a way following the Minbari tradition of "going to the sea". His Whitestar is found sealed, and his body never discovered. It is believed that he was taken beyond the rim of the galaxy, not into death, but rather to dwell with the First Ones until humanity itself passed beyond the rim.
- On Earth, upon hearing an ISN report on the death of John Sheridan, Alfred Bester passes away in his jail cell.
- Babylon 5 is demolished by Earthforce due to waning traffic over the years. 
- Thursday, January 20th, 2281
- The Interstellar Alliance's twenty year agreement with the Yolu Ingyo to intercede in all border disputes in Sector 800 expires.
|Before the Third Age:||20th Century and earlier 21st Century 22nd Century 2200s 2210s 2220s 2230s 2240s|
|2250s:||2250 2251 2252 2253 2254 2255 2256 2257 2258 2259|
|2260s:||2260 2261 2262 2263 2264 2265 2266 2267 2268 2269|
|2270s onwards:||2270s 2280s 2290s 2300s and beyond|