Katsulas is recognized as the murderous one-armed man in the 1993 thriller The Fugitive. He is also known for playing the recurring character of Romulan Commander Tomalak on Star Trek: The Next Generation. He had a small role in the hit Kurt Russell film Executive Decision.
A lifelong smoker, Katsulas was diagnosed with lung cancer in early 2005. He passed away on February 13, 2006, at the age of 59.