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Immortality is a state where a life-form will live a theoretically endlessly lifespan, though are still susceptible to injury or illness.
Several of the races collectively known as the First Ones, including the Vorlons and the Shadows, are believed to have achieved various forms and means of immortality with the Shadows able to enter a state of hibernation for at least a millennia.
The Dilgar War Master, Jha'dur, invented a universal anti-agapic serum that could sustain someone indefinitely as long as they took another person's life to complete the formula. The Vorlons destroyed Jha'dur and all traces of the serum.