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Omega may refer to:
- EAS Omega, an Earthforce transport vessel.
- Omega 7, an Earth Alliance mining colony.
- Omega Colony, an Earth Alliance colony.
- Omega class destroyer, a class of capital ships in the Earthforce fleet.
- Advanced Omega class destroyer, an experimental version of the Omega class destroyer using Shadow technology.
- Omega sector, a region of space out on the rim that included Thenothk and Z'ha'dum.
- Alpha Omega 3, the IPX designation for a mysterious world out on the rim.
- Black Omega, an elite Psi Corps Starfury squadron.
- Sacred Omega, one of several Human doomsday cults that came to prominence after the Drakh attack of Earth.